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詳細(xì)解析ALZET滲透泵的使用優(yōu)點和工作機制
發(fā)布時間： 2022-07-19 點擊次數(shù)： 1048次ALZET滲透泵已被用于數(shù)千項關(guān)于受控輸送各種實驗藥物的影響的研究，包括肽、生長因子、細(xì)胞因子、化療藥物、成癮藥物、激素、類固醇和抗體。由于ALZET滲透泵運行的*機制，任何分子構(gòu)象的化合物都可以以受控的速率以可預(yù)測的方式輸送，而與它們的物理和化學(xué)特性無關(guān)。ALZET滲透泵的優(yōu)點：1、確保連續(xù)不斷的暴露在預(yù)定水平的測試藥物下；2、可以執(zhí)行短效期的蛋白質(zhì)及氨基酸給藥；3、提供了動物慢性定量給藥的簡單方法；4、解決了夜間及周末給藥的不便困擾；5、減少了對實驗動物的操作和應(yīng)激影響；6、足夠小到可以應(yīng)用到小鼠及年幼大鼠；7、可以向幾乎任何組織用藥；性價比很高的研究工具。ALZET滲透泵的工作機制：ALZET滲透泵的運行主要是因為泵內(nèi)滲透層的隔室與植入泵所在組織環(huán)境間存在的滲透壓差。滲透層的高滲透壓使組織中的水分通過泵外表面的半透膜流入泵中，當(dāng)水進(jìn)入滲透層時，它會壓縮柔性儲液罐，以受控的預(yù)定速率將測試溶液從泵中排出。由于無法重新填充壓縮儲液罐，因此泵僅設(shè)計為一次性使用。本產(chǎn)品的輸送速率是由泵外膜的透水性控制，因此泵的輸送曲線與分配的藥物制劑無關(guān)。各種分子構(gòu)型的藥物，包括電離藥物和大分子，可以在各種兼容的載體中以受控的速率連續(xù)分配。化合物的分子量或其物理和化學(xué)性質(zhì)與其通過ALZET滲透泵的輸送速率無關(guān)。ALZET滲透泵的容積輸送率在制造時是固定的。ALZET滲透泵具有0.11~10µL/hr之間的各種輸送速率和1天~6周之間的輸送持續(xù)時間。雖然泵的體積輸送速率是固定的，但可以通過改變用于填充泵儲液器的溶液或懸浮液中的藥劑濃度來實現(xiàn)不同的給藥速率。
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